Team: University of Leeds (UK)
Review: Gene Therapy
Researchers at Leeds University have shown, in vitro, by integrating a virus protein targeting a marker expressed by tumor cells of the bladder (and possibly other cancers), that selectively penetrated into these tumor cells. They also showed that by integrating these proteins ("retargeting proteins") to an existing viral vector for gene therapy, they increased the sensitivity of tumor cells to chemotherapy cancer.
cancer gene therapy, somewhat maligned in recent years because of its lack of specificity vis-à-vis the cancer cells would thus, in humans, increase the effectiveness of chemotherapy, or even repair genetic modifications to the origin of tumors.
The interest of this study is to increase the selectivity of viral vectors in gene therapy, and is successful enough, apparently. It is also possible, thanks to this discovery, target multiple tumor types with the same vector, simply by integrating multiple protein targeting. Similarly, by analyzing the surface antigens of the patient's tumor, it could "build" a specific virus, expressing the target proteins effective against the tumor.
http://www.medicalnews-blog.fr/index.php?post/2010/04/28/Modifier-un-virus-afin-qu-il-traque-et-detruise-les-cellules-cancereuses
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